Andrew Huberman· PhD
There are specific sequences of DNA that this complex vitamin D re bound the vitamin D receptor goes inside and recognizes and turns on a whole host of genes, turns off a whole host of genes.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
There are specific sequences of DNA that this complex vitamin D re bound the vitamin D receptor goes inside and recognizes and turns on a whole host of genes, turns off a whole host of genes.
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One of the important things that I think drives home the biological activity of vitamin D is the fact that you can actually identify likely genes that interact with vitamin D by a special sequence called a VDRE.
when you get it it binds to the vitamin D receptor this causes the vitamin D receptor to heterodon receptor and this complex then goes inside the nucleus of the cell where the DNA is and it recognizes a little Telltale sequence in the DNA called a vitamin D response element which is essentially two repeats of six nucleotides separated by three nucleotides and the sequence itself actually determines whether or not a gene is going to be be turned on to be more active to do its function or going to be turned off