Andrew Huberman· PhD
Well, the enzyme that does that in your brain is called tryptophan hydroxylase-2, and it's activated by vitamin D.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Well, the enzyme that does that in your brain is called tryptophan hydroxylase-2, and it's activated by vitamin D.
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the VDRES in tryptophan hydroxilase 2. So for people listening, tryptophan hydroxilase is an enzyme that converts tryptophan into serotonin. So tryptophan is what we uh an amino acid that we get from our food. Um you convert serotonin, you convert tryptophan into serotonin into the gut in the gut, but you also do it in the brain. However, serotonin does not cross the bloodb brain barrier. So tryptophan has to get into your brain and then you have to convert it to serotonin in your brain. Well, the enzyme that does that in your brain is called tryptophan hydroxilase 2 and it's activated by vitamin D.
Vitamin D as a regulator of serotonin could implicate it in neurodevelopment and neuropsychiatric disorders beyond ADHD. In my 2015 follow-up, co-authored with Dr. Bruce Ames, we discuss relevance for ADHD, bipolar disorder, schizophrenia, and more.
In 2014 I published a paper showing in silico evidence that vitamin D regulates the gene (TPH2) that converts tryptophan into serotonin in the brain.
that neurotransmitter very very important neurotransmitter that's regulating a whole host of cognitive function and behaviors including social behavior emotion aggression anxiety um cognition memory appetite
I found that vitamin D increases the expression of a gene called tryptophan hydroxylase 2 in your brain and this Gene is responsible for the conversion of tryptophan into serotonin
vitamin D hormone I mentioned you know activates this Gene tph2 I'm really driving this home to make serotonin in the brain