Rhonda Patrick· PhD
These data suggest that correcting vitamin D deficiency may help lower the risk of opioid use disorder.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
These data suggest that correcting vitamin D deficiency may help lower the risk of opioid use disorder.
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People with insufficient vitamin D levels were 50% more likely to have opioid use disorder and those with severe deficiency were 90% more likely to abuse opioids compared to people with normal vitamin D after correcting for confounding factors.
Vitamin D deficiency increased rewarding effects of UV exposure & sensitized mice to the pain-relieving/rewarding effects of opioids.