Rhonda Patrick· PhD
Vitamin D reduced dementia risk by 33% in adults with mild cognitive impairment or APOE e4, a key genetic risk factor for neurodegenerative diseases.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Vitamin D reduced dementia risk by 33% in adults with mild cognitive impairment or APOE e4, a key genetic risk factor for neurodegenerative diseases.
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Vitamin D supplementation was associated with a 40% lower risk of dementia over a decade, a relatively recent study shows.
After five years, 84% of supplement users were dementia-free compared to just 68% of non-users in a study of over 12,000 people.
Women, adults with normal cognition, APOE e4 non-carriers, and those without depression saw the greatest brain-protective effects from vitamin D supplementation.
Adults moderately or severely deficient in vitamin D had a 53% or 125% increased risk of dementia.
Adults moderately or severely deficient in vitamin D had a 53% or 125% increased risk of dementia.
Vitamin D supplementation was associated with a 40% lower risk of dementia over a decade.
Vitamin D reduced dementia risk by 33% in adults with mild cognitive impairment or APOE e4, a key genetic risk factor for neurodegenerative diseases.
After five years, 84% of supplement users were dementia-free compared to just 68% of non-users in a study of over 12,000 people.
And vitamin D reduced dementia risk by around 33% in adults with mild cognitive impairment and also had APOE E4.
And this was also true regardless of whether or not the participants had baseline mild cognitive decline or normal cognitive function. So vitamin D seemed to provide a benefit in both of those scenarios.
After just 5 years, 84% of the vitamin D supplement users were dementi free compared to 68% of the non-users.
So this data really strengthens the argument that low vitamin D can increase dementia risk and that supplementing with vitamin D can help lower that risk.
So for example, women derived the greatest benefit from vitamin D, um they actually experienced less dementia compared to men who supplemented. And while vitamin D using men had a 26% lower dementia incidence than non-users, vitamin D using women had almost a 50% lower incidence compared to non-using women.
It also didn't matter what form vitamin D was used. All of them were associated with a lower dementia risk.
Adults that had normal baseline cognitive function had a 56% lower dementia incidence if they supplemented with vitamin D. But adults that did have mild cognitive impairment only had a 33% lower incidence of dementia if they supplemented.
Participants with mild cognitive impairment who didn't supplement with vitamin D had more than a 600% increase in dementia risk compared to the adults with normal normal cognitive function even those who didn't use vitamin D.
So in other words, even if you already had some sort of mild cognitive impairment, you still had a lower risk of actually transitioning to dementia if you were supplementing with vitamin D.
A new study found that vitamin D supplementation was associated with a 40% lower risk of dementia over a decade.
The same was true for another risk factor having mild cognitive impairment which elevated dementia incidents by nearly 400% compared to people that had normal cognitive function even in the presence of vit vitamin D supplementation.
There was a 10-year follow-up. And during that period, supplementing with vitamin D was associated with a 40% lower incidence of dementia.
So, people that had APOE4 that supplemented with vitamin D did reduce their incidence of dementia by around 33%. And among non-arriers, vitamin D reduced the incidence of dementia by 47%, a little bit higher, which is not surprising.
Supplementing with vitamin D was also associated with a greater 5-year dementiareree survival. So 84% of adults in the vitamin D group were free of dementia during this time period while only 68% of the nonvitamin D users were de dementi-free during that same period.
Using combined forms of vitamin D was associated with a 50% lower risk.
These participants still had a 16% greater risk of dementia than non-arriers, even non-arriers who didn't use vitamin D.
And supplementing with vitamin D wasn't enough to outweigh the effects of carrying one or two copies of APOE4.
Specifically using calcium vitamin D was associated with a 44% lower risk of dementia. And using vitamin D3 was associated with a 37% lower risk of dementia. And then using vitamin D2, which is the plant version, was actually associated with a 50% lower risk of dementia.
And then on the flip side of that, there have also been studies that have shown people that supplement with vitamin D are about 40% less likely to get dementia. So it decreases dementia risk by 40%.