Peter Attia· MD
For vitamin D supplementation to have any effect relative to placebo, it needs to be increasing the body’s supply of vitamin D.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
For vitamin D supplementation to have any effect relative to placebo, it needs to be increasing the body’s supply of vitamin D.
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a better vitamin D trial would be we take a bunch of people whose vitamin D is below 30 in one group we give a placebo and in another group we give whatever it takes to get them to I'm making this up at 80 then we would see is there a difference between this group that's below 30 and this group that gets to 80
to me the dispositive study on this would be take a whole bunch of people whose vitamin D is 30 give half of them a placebo give half of them whatever vitamin D is necessary to get them to 60 or 80 80 yeah get something higher yeah get create separation go 30 to 40 but be like do it the way we do blood pressure trials when we do a blood pressure trial we don't say you're going to take a fixed dose of a med we give you whatever dose of the med is necessary to change the blood pressure so we're comparing two blood pressure levels not Placebo versus 10 milligram of a drug that for one guy is too much and for one guy is too little and yet this isn't done in vitamin D