The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
And by the way, there have been studies looking at people that are deficient in vitamin D. In this case, it was African Americans that were given a 4,000 IU a day vitamin D supplement to bring them back to sufficient levels. This was a smaller study than I would like, but it reversed their epigenetic aging by three years.
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And by the way, there have been studies looking at uh people that are deficient in vitamin D. Um, in this case it was uh African-Americans that were given a 4,000 IU a day vitamin D supplement to bring them back to sufficient levels. And um this was a this was a smaller smaller study than um I would like but it reversed their epigenetic aging by like 3 years because again it's a hormone. It's regulating more than 5% of your protein encoding human genome.
Other studies have shown if you're vitamin D deficient, severely vitamin D deficient, like African-Americans, for example, who are obese or overweight, if they add in vitamin D and supplement with 4,000 IUs a day for six um 6 weeks, they can actually slow their ep reverse their epigenetic aging as well.
Supplementing with 4,000 IU of vitamin D per day for 16 weeks reversed epigenetic aging by 1.85 years in overweight and obese African Americans that were low in vitamin D (randomized-placebo controlled trial).
Supplementing with 4,000 IU of vitamin D per day for 16 weeks reversed epigenetic aging by 1.85 years in African Americans that were low in vitamin D.
their epigenetic clocks were measured at baseline and after and the epigenetic clock horvath the horopoth clock was was used um it's it basically was reduced by 1.8 years or something like that
one study that took people that were vitamin D deficient and that's it's important to to start out with a cohort of participants that are deficient sh right because if you already have someone that's sufficient giving them a vitamin D supplement really shouldn't do much because they're already at a sufficient level so um these were African-American individuals that were also overweight and um so they were they were very vitamin D deficient they were given a vitamin D supplement with 4,000 IUS of vitamin D a day and it decreased their epigenetic age by almost 2 years
So, people with vitamin D deficiency have accelerated epigenetic aging. If you look at the DNA and you look at um these methylation groups that are kind of sitting on top of DNA, there's a pattern of these methylation groups as we age. And uh you know Dr. Steve Horvath developed the first epigenetic clock uh that was really able to to to categorize this aging. But um there's been subsequent clocks developed since that clock with also you know Dr. forbath and others. Um, looking at actually your biological age and so you can look at your biological age and it kind of gives you an idea of how well your body is aging. I I would say it's one of the factors. It's not my favorite, but it's one. So, people with vitamin D deficiency have accelerated epigenetic aging. If you take vitamin D. In this in this case, um, these people were African-American and they were obese. There two compounding effects in terms of causing their vitamin D deficiency. they were severely deficient and they were given 4,000 IUs of vitamin D per day for about a month and that reversed their epigenetic age by almost 2 years.