Andrew Huberman· PhD
It's also involved in vitamin D metabolism. And, in fact, being deficient in magnesium may make it more difficult for you to actually make vitamin D hormone, so that 1,25-dihyroxyvitamin D.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
It's also involved in vitamin D metabolism. And, in fact, being deficient in magnesium may make it more difficult for you to actually make vitamin D hormone, so that 1,25-dihyroxyvitamin D.
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you do need magnesium in order to activate vitamin d so that would be number two nutrient um if you want to get the most benefits of your vitamin d make sure you have good magnesium status
suboptimal levels of magnesium um will also uh impede um metabolism of vitamin D and and therefore um we we will see low magnesium associated with low vitamin D because magnesium is a co-factor in the enzymatic conversion of vitamin D
If you're supplementing with vitamin D3 but fall into the 50% of the population with insufficient magnesium, the conversion of D3 to 25OHD and subsequently to its active steroid hormone form may be compromised.
A randomized controlled trial found that magnesium is vital for converting vitamin D3 into its active form, particularly enhancing 25OHD levels in individuals with inadequate vitamin D, thus stabilizing vitamin D status.
Magnesium plays a crucial role in the metabolic processes that convert vitamin D into its active steroid hormone form.
if half the US population is not getting enough magnesium and magnesiums required to make vitamin D function as an active steroid hormone then you're going to have a problem those trials are they're going to be flawed at the get-go
magnesium's influence on vitamin D status is not a one-size fits all it really varies based on your existing vitamin D levels it's playing a critical role in either helping stabilize vitamin D in the body converting that vitamin D3 into that active that that stable circulating form or it's also activating that c that circulating stabilized form 25 hydroxy vitamin D into the active steroid hormone depending on your individual needs
magnesium is key for enzymes that convert vitamin D3 into 25 hydroxy vitamin D which is the main circulating form of vitamin D in our bodies so this Tri trial showed that for people with low 25 hydroxy vitamin D levels which usually can indicate vitamin D deficiency magnesium supplementation effectively increase these levels
if a person's magnesium intake is adequate this can enhance the body's ability to maintain healthy levels of vitamin D on the other hand if magnesium intake is low like 45% or half the population roughly of the US that may hinder the body's ability to utilize vitamin D effectively even if vitamin D intake is sufficient