The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Basically, the point is that vitamin D is a steroid hormone, meaning it actually binds to a receptor and another receptor dimerizes with it, the retinoid receptor, and that complex goes into the nucleus of a cell, where your DNA is, and it recognizes little sequences of DNA called vitamin D response elements.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
chole calciferol vitamin d3 is transformed into 25 hydroxy vitamin d by the liver and then further transformed into calcitriol 125 dihydroxy vitamin d at the level of the kidney
D3 is converted into 1,25-dihydroxyvitamin D. So there's two steps. One in the kidney, one in the liver in mammals that does that conversion.
So vitamin D3 goes to the to the liver. It's converted to a another metabolite called 25 hydroxy vitamin D. That's the major circulating metabolite of vitamin D. That's usually measured if you get a blood test. And then it goes to the kidneys where it's then converted into the steroid hormone. That's 125 hydroxy vitamin D.