Caloric restriction (CR) may extend lifespan. People who did 14% CR for 2 yrs had gene exp

Well SupportedCaloric restriction improves inflammatory markers, including IL-6, TNF-alpha, and high-sensitivity CRP, and reduces fat involution in the thymus.

Partially SupportedSustained caloric restriction for two years in humans leads to gene expression changes in fat tissue, including NAMPT and Pla2g7.

Partially SupportedGene expression changes with sustained caloric restriction in humans are similar to those seen after bariatric surgery and exercise.

Partially SupportedDeletion of Pla2g7 in mice reduces inflammation and maintains a youthful immune system.

Partially Supported