@SallySamsara @BioLayne This is a classic example of reverse causation. Correlation does n

Well SupportedHigher levels of low-density lipoprotein cholesterol (LDL-c) are associated with a reduction in lifespan and longevity.

Well SupportedHigher levels of APOB and LDL are associated with shortened healthspan and increased Alzheimer's risk.

Partially SupportedLow LDL-C levels in older adults can be a marker of underlying illness or frailty, not a direct cause of mortality.

Well SupportedMendelian randomization (MR) uses genetic variations to establish causality between factors like high cholesterol or smoking and diseases, acting as a natural experiment.

Well Supported