@PeterFaberSP @rajatkumar12 @BioLayne https://t.co/UEemRKpV54 [@foundmyfitness: @SallySams

Well SupportedHigher levels of low-density lipoprotein cholesterol (LDL-c) are associated with a reduction in lifespan and longevity.

Well SupportedHigher levels of APOB and LDL are associated with shortened healthspan and increased Alzheimer's risk.

Well SupportedMendelian randomization (MR) uses genetic variations to establish causality between factors like high cholesterol or smoking and diseases, acting as a natural experiment.

Partially SupportedLow LDL-C levels in older adults can be a marker of underlying illness or frailty, not a direct cause of mortality.

Well Supported