When your brain is under high cognitive stress, like sleep deprivation, aging, or intense

Well SupportedSupplemental creatine can enhance cognitive function, particularly under conditions of high cognitive stress such as sleep deprivation, aging, or intense mental demands.

Well SupportedA dose of 20 grams of creatine taken acutely during periods of extreme stress like sleep deprivation or jet lag can improve memory, cognition, and brain creatine content.

Well SupportedCreatine supplementation may enhance the function of frontal cortical circuits involved in mood regulation and motivation, potentially assisting in mild depression.

Well SupportedCreatine may play a role in stabilizing brain energy metabolism, potentially protecting against mood disturbances, cognitive fatigue, and traumatic brain injury.