Creatine supplementation may enhance the function of frontal cortical circuits involved in mood regulation and motivation, potentially assisting in mild depression.

“And that's where creatine plays a role in depression, or rather, where creatine supplementation seems to be able to assist in some forms of mild depression. That's an emerging literature. It's still not well-established.”

“it's quite clear that the bulk of scientific studies have examined the role of creatine in the clinical context and as its role in improving cognitive performance.”

“it is very clear to me based on the literature • that you described and some of which we've covered on other episodes of the podcast that the phosphocreatine system is vitally important for forbrain function right the forbrain of course being the the • portion of brain U broadly speaking the portion of brain just behind your forehead that is • responsible for planning action setting rules in context”

“Creatine can actually be used as a fuel source in the brain and there's some evidence that it can enhance the function of certain uh frontal cortical circuits that feed down onto or rather connect to areas of the brain that are involved in mood regulation and motivation.”

“the phosphor creatine system seems to be somewhat um biased towards fourbrain structures. You know, I mean obviously it's in lots of brain areas, but that there might be a heavier reliance on it for >> brain areas that are associated with strategic planning and you know, working memory and Yeah. If you if you were to sort of just map the the the sort of density of usage of the phosphocreatine system, you'd you'd see a frontal bias for sure.”

“but brain aging in general yeah I'm obviously chronologically aging and there is some degree of aging going on in my brain but you know so that's that's I think where the creatine crazes come from is the interest in”

“researchers started to find out that well, you can't just take creatine and it's going to enhance cognitive function. It's in the background of stressing the brain, right? you're stressing your muscles by a workout. Same goes for the brain. It's like in these situations of stress, whether that's sleep deprivation, whether it's, you know, a traumatic brain”

“these studies consistently show benefits in terms of cognition even in people who are not aging or have cognitive decline but certainly in people who have cognitive decline creatine is beneficial”

“in multiple studies creatine supplementation improves cognitive function that seems the greatest effect seems to be in those who are oldest but if you have some deficit in cognitive function which may be related to creatine if it's through a concussion then a supplementation may be beneficial”

“Possibly staves off cognitive decline”

“These findings complement those of a prior publication showing higher brain creatine levels and improved cognition in the same participants.”

“Longer-term supplementation (5 g/day over several weeks) in older adults improves memory recall and cognitive clarity.”