Why maintaining weight loss is more challenging than losing weight | Peter Attia and David Allison

Partially SupportedThe modern food supply in developed countries is likely the safest in history, with reduced exposure to microbes and toxins compared to historical periods.

Partially SupportedThe 'thrifty gene' hypothesis suggests that selection favors individuals predisposed to consuming more food when available, which could be advantageous in environments with unpredictable food scarcity.

Partially SupportedThe Frisch hypothesis suggests extreme thinness in women can cause amenorrhea and reduce reproductive fitness.

Partially SupportedThe observation that animals always consume available food is not universally true, as demonstrated by fish sometimes ignoring bait.