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Weekly · Sunday Morning

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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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What are the “ABCs” of Alzheimer’s prevention? (Qualy #24) — Whalespan

Content›Video›What are the “ABCs” of Alzhe…

What are the “ABCs” of Alzheimer’s prevention? (Qualy #24)

Peter Attia11m · 2020-02-13

Support Rate

64%

16 of 25 claims supported

Support rate

16 of 25 claims supported

16 supported9 partial / not

Claims from this content

10

✓Well SupportedFunding for Alzheimer's research should be balanced between treatment and prevention, with a potential split favoring prevention.✓Well SupportedSeeing biomarkers improve provides positive reinforcement for patients actively engaged in their health.◐Partially SupportedAn N-of-one approach leads to the most success in health and longevity.◐Partially SupportedHigh-intensity interval training (HIIT) is necessary for significant weight loss, whereas 20 minutes of elliptical training three times a week is insufficient.✕Not SupportedDetailed lipid profiling, including apolipoprotein B, LDL particle number, and particle subtypes, is important for Alzheimer's prevention.

More from Peter Attia

Peter Attia on Zone 2 Cardio

Peter Attia on Rapamycin (with Matt Kaeberlein)

Attia walks back the clinic protocol: too aggressive for healthy adults

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AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

NP

N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐Partially SupportedChanging lifestyle behaviors like sleep, meditation, exercise, and diet can have a greater impact on health outcomes than taking a pill.

◐Partially SupportedA precision medicine approach considering cholesterol, inflammation, metabolism, nutrition, genetics, body fat, and cognitive function can lead to personalized plans with better outcomes.

◐Partially SupportedMeasuring TNF-alpha, interleukins, and CD50s would provide valuable data.

◐Partially SupportedMyeloperoxidase is a newly identified risk factor for vascular cognitive impairment.

◐Partially SupportedThe 'ABCs' of Alzheimer's prevention include anthropometrics, blood-based biomarkers, and cardiovascular health.