Raising NAD levels reduces inflammation in humans. At least 8 randomized controlled trials

Well SupportedBoosting NAD levels can activate sirtuin defenses and DNA repair proteins.

Well SupportedNAD depletion is a hallmark of chronic inflammatory states.

Partially SupportedRestoring NAD with precursors like NR may help break the cycle of inflammation and NAD depletion by supporting natural repair, detoxification, and anabolic processes.

Partially SupportedApproximately 1 gram per day of nicotinamide riboside (NR) lowers key inflammatory cytokines, including IL-6 and TNF-α, based on at least 8 randomized controlled trials.

Well Supported