Andrew Huberman· PhD
And NAD in the body works to activate one of those longevity switches called sirtuins, which are involved in DNA repair.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
And NAD in the body works to activate one of those longevity switches called sirtuins, which are involved in DNA repair.
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if we kept cells with high amounts of nad they would survive better DNA damage others insults
and the idea is that by either replacing lost nad or boosting it to levels that you would only get if you run marathons constantly you can turn on these sirtuin defenses and other aspects like DNA repair proteins that need nad
Point two is a class of proteins called certuins rely heavily on NAD as the substrate in the process of repairing DNA.
NAD is required for DNA repair, mitochondrial energy production, sirtuin signaling, and antioxidant defenses.
Why NAD fuels DNA repair