Story @nature about the challenge of discovering safe epigenetic reprogramming to reverse

Well SupportedThe initial targets for the ER-100 epigenetic reprogramming therapy are age-related eye diseases such as glaucoma and optic nerve damage.

Partially SupportedA method using three reprogramming genes (OCT4, SOX2, and KLF4, OSK) can reset the biological age of human cells without inducing stem cells.

Partially SupportedThe ER-100 method aims to reset the epigenetic clock and address the root cause of cellular aging.

Partially SupportedThe ER-100 epigenetic reprogramming therapy avoids using c-MYC to reduce the risk of uncontrolled cell growth.