Small correction here. You don’t need to reach a core temperature of 102.3°F to activate H

Well SupportedSitting in a sauna at 163°F (73°C) for 30 minutes increased heat shock proteins, including Hsp70, by 50% over baseline, with the elevation sustained for 48 hours.

Well SupportedDry sauna activates heat-shock proteins in the skin, and a modest 1°C increase in core temperature is sufficient for this activation without risking hyperthermia.

Partially SupportedBryan Johnson's previous sauna protocol of 20 minutes at 200°F (93°C) likely did not reach the heat shock protein threshold of 102.4°F (39°C) core body temperature.

Well SupportedSauna protocols comparable to Bryan Johnson's have been linked to significant reductions in all-cause mortality, fatal heart disease, and high blood pressure, as well as a reduction in hsCRP.