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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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I Tried Psilocybin for Science (Livestream Highlights) — Whalespan

Content›Video›I Tried Psilocybin for Scien…

I Tried Psilocybin for Science (Livestream Highlights)

Bryan Johnson25m · 2025-12-11

Claims Made

34

Claims Supported

23

Support Rate

68%

Support rate

23 of 34 claims supported

23 supported11 partial / not

Claims from this content

19

✓Well SupportedBryan Johnson is taking 5.24 grams of dried B+ strain mushrooms, containing 28 mg of active psilocybin, as part of a quantified psychedelic experiment.✓Well SupportedThe epigenome regulates gene expression, and its dysregulation during aging may be a primary cause of aging.◐Partially SupportedPsilocybin is being explored for potential rejuvenation and longevity effects.✓Well SupportedNavy Seals have reported that a single ibogaine treatment in Mexico cured them of PTSD, depression, addiction, and traumatic brain injury.Partially Supported

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Bryan Johnson's Blueprint Rapamycin Protocol

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐

An experiment is measuring 249 biomarkers to quantify the effects of psilocybin.

◐Partially SupportedResearcher Gul Dolan hypothesizes psychedelics open critical periods and is testing psilocybin's effect on motor control recovery in stroke victims.

◐Partially SupportedPsychedelics can accelerate the achievement of spiritual states compared to meditation.

◐Partially SupportedIbagane may help individuals overcome opiate addiction.

◐Partially SupportedPsilocin reaches maximum concentration in blood plasma 1.5 to 2 hours after oral psilocybin ingestion.

◐Partially SupportedTaking psilocybin can reduce inhibitions, leading to a state where one is more willing to think and say anything without internal checks.

◐Partially SupportedReaction time testing is part of the health assessment.

◐Partially SupportedCompounds in mushrooms may reset the epigenome and restore youthful tissue function.

◐Partially SupportedPsychedelic substances may change gene expression profiles and lead to rejuvenating effects.

◐Partially SupportedPsychedelic experiences can be beneficial and help demystify the substances.

◐Partially SupportedMushrooms are relatively harmless, especially in small quantities.

◐Partially SupportedBaseline measurements for an experiment include saliva testing, thermal body heat measurement, blood pressure, and brain oxygen monitoring.

◐Partially SupportedCompounds like MDMA and psilocybin may be reclassified for prescription by physicians in the United States.

◐Partially SupportedThe Colonel device measures oxygen in the brain to map brain activity and analyze drug interactions or mental states.

◐Partially SupportedThe experience of taking psilocybin can alter consciousness, changing perception and filtering thoughts.