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Weekly · Sunday Morning

Five longevity claims.
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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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How insulin is beneficial for humans — Whalespan

Content›Video›How insulin is beneficial fo…

How insulin is beneficial for humans

Paul Saladino5m · 2022-07-23

Claims Made

11

Claims Supported

10

Support Rate

91%

Support rate

10 of 11 claims supported

10 supported1 partial / not

Claims from this content

8

✓Well SupportedInsulin has anti-natriuretic actions in the kidney, helping prevent electrolyte loss.✓Well SupportedIt is not possible to adequately supplement electrolytes to maintain normal levels on a ketogenic diet.◐Partially SupportedElectrolyte issues develop when insulin signaling is limited by not eating carbohydrates, and this disruption cannot be fixed by electrolyte supplementation.◐Partially SupportedInsulin can directly increase the activity of epithelial sodium channel, sodium phosphate transporter, sodium hydrogen exchanger type 3, and sodium potassium ATPase.Partially Supported

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AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐

Excess omega-6 fatty acids like linoleic acid are a major driver of human metabolic dysfunction, more so than insulin resistance induced by insulin.

◐Partially SupportedCarbohydrates, especially from fruit and honey, do not cause insulin-induced insulin resistance in humans, and insulin has beneficial effects.

◐Partially SupportedIt is virtually impossible to develop insulin-induced insulin resistance outside of a laboratory setting with a continuous insulin drip.

✕Not SupportedInsulin resistance is typically caused by metabolic derangements related to seed oils, specifically excess linoleic acid.