Audit a URL →

Sign in Sign up free

Loading…

Weekly · Sunday Morning

Five longevity claims.
Worth your time.
Every Sunday.

Last Sunday

Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

5 audits·1 verdict change·0 affiliate links·Every Sunday

Joining 1,247 readers — founders, MDs, and longevity-obsessed people who fact-check their own health decisions.

Browse

Decisions Claims Content Creators

Product

Audit a URL Sunday roundup API (soon)Pricing

About

FAQ Methodology Editorial Standards Corrections Press & brand RSS feed

Legal

Terms of Service Privacy Policy DMCA

Finally, something serious in this space.
Because we actually read the papers.

© 2026 Whalespan. Independent, evidence-graded longevity.

The flawed history of Statins — Whalespan

Content›Video›The flawed history of Statin…

The flawed history of Statins

Paul Saladino15m · 2022-09-04

Claims Made

35

Claims Supported

0

Support Rate

0%

Support rate

0 of 35 claims supported

0 supported35 partial / not

Claims from this content

21

◐Partially SupportedChanges in trial guidelines in 2004 affected the assessment of statin efficacy.◐Partially SupportedA significant portion of the panel recommending lower statin prescription thresholds had financial ties to cholesterol-lowering drug manufacturers.◐Partially SupportedMeta-analyses of statin trials can obscure details by mixing trials of varying quality and time periods.✕Not SupportedPaul Saladino avoids mushrooms and foods like leaves, stems, roots, and seeds that contain defense chemicals.Partially Supported

Discussion

Native comments, Twitter mentions, and Reddit threads about this content — surfaced together so the conversation isn't fragmented across platforms.

M

Share your read of this content…

Posting publicly as you · linked to your social profiles

Sort by:

AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

NP

N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐

Lovastatin, the statin found in red yeast rice, is a mycotoxin that inhibits HMG-CoA reductase.

◐Partially SupportedStatin trials after 2004 showed minimal to zero absolute risk reduction in all-cause mortality.

◐Partially SupportedSome research suggests potential pharmacological mechanisms by which statins might stimulate atherosclerosis and heart failure.

✕Not SupportedThe CTT collaborative's reviews of statin data advocate for wider statin use in healthy individuals over 50 regardless of cholesterol levels.

◐Partially SupportedIn the 4S trial, statin benefit was not significant for individuals without low HDL and high triglycerides.

◐Partially SupportedLack of independent funding for most statin trials and the ALLHAT trial suggest potential industry influence.

◐Partially SupportedMonacolin K, found in red yeast rice and oyster mushrooms, is a mycotoxin that fungi produce to deter predation.

◐Partially SupportedThe Pravastatin Heart Attack Trial showed no significant benefit of pravastatin in reducing all-cause mortality or coronary heart disease in primary prevention.

◐Partially SupportedStatin trials before 2004 showed significant improvement in cardiovascular event ratios for primary and secondary prevention based on LDL levels.

✕Not SupportedBayer recalled the statin cerivastatin in 2001 due to serious side effects.

◐Partially SupportedNICE proposed lowering the statin risk threshold from 20% to 10% over 10 years, facing doctor objections.

◐Partially SupportedCholesterol guidelines were revised in 2000 and 2004 without new data, lowering acceptable levels and increasing statin eligibility.

◐Partially SupportedCTT Collaboration recommendations suggest over half the US population over 35 would start statin therapy if implemented.

◐Partially SupportedAn NIH panel in 1990 concluded that lowering LDL might not be beneficial and advised caution, but this conclusion was largely ignored.

◐Partially SupportedThe diet-heart hypothesis, which posits that cholesterol causes atherosclerosis, originated in 1913 when rabbits fed cholesterol developed atherosclerosis.

◐Partially SupportedRabbit atheromas from cholesterol feeding do not resemble human atheromas.

◐Partially SupportedFeeding humans pure cholesterol does not necessarily lead to the development of atheromas.