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Weekly · Sunday Morning

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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Should you be fasting? — Whalespan

Content›Video›Should you be fasting?…

Should you be fasting?

Paul Saladino9m · 2022-07-29

Claims Made

18

Claims Supported

10

Support Rate

56%

Support rate

10 of 18 claims supported

10 supported8 partial / not

Claims from this content

14

✓Well SupportedFasting requires meeting protein and other nutritional needs to avoid negative consequences.✕Not SupportedFasting should not be used as a license to reduce movement, as this can lead to muscle catabolism.◐Partially SupportedKeto diets require responsible implementation with awareness of potential long-term negative effects.✕Not SupportedMany in the longevity community who advocate extreme fasting or protein restriction may lack lean muscle mass and have compromised hormones.✕Not Supported

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AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

NP

N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Fasting practices that impinge on sleep quality, such as eating within a narrow window close to bedtime, should be avoided.

◐Partially SupportedThe speaker's current health metrics include very low inflammation (hs-CRP 0.5), low fasting insulin, and IGF-1 half a standard deviation below the mean.

◐Partially SupportedConsuming about 50% of daily calories earlier in the day and tapering off with a lighter dinner can improve sleep quality.

◐Partially SupportedNot eating breakfast and continuing intermittent fasting prolongs the natural morning cortisol awakening response.

◐Partially SupportedThe speaker practices intermittent fasting with an eating window from 11 AM to 8 PM and sleeps from 10 PM to 5-6 AM.

✓Well SupportedEating earlier in the day and tapering off later aligns with circadian rhythms and optimizes glucose disposal and insulin sensitivity.

◐Partially SupportedThe speaker prioritizes optimizing sleep and avoids eating within three hours of going to sleep.

◐Partially SupportedEarly time-restricted feeding may be marginally better than skipping breakfast, potentially due to increased cognitive awareness.

◐Partially SupportedBeing active is important, regardless of whether one is fasting.

✕Not SupportedConsistently eating after sunset is likely detrimental to health.