The relationship between testosterone levels and prostate cancer aggressiveness

Partially SupportedTestosterone supplementation does not cause prostate cancer but can accelerate the growth of existing prostate cancer.

Partially SupportedMore aggressive prostate cancers are less reliant on Androgen Receptor engagement for growth compared to less aggressive tumors.

Partially SupportedProstate tumors with gene expression signatures reflecting very low Androgen Receptor signaling and amplification of PTEN and MYC are associated with a more aggressive phenotype, including metastasis, progression, and resistance to traditional therapies.

Partially SupportedAn mRNA-based assay can characterize gene expression, including Androgen Receptor gene expression, within prostate tumors.

The relationship between testosterone levels and prostate cancer aggressiveness | Ted Schaeffer