New findings on ApoB & atherosclerosis

PS

Paul Saladino14m · 2023-12-26

Claims Made

20

Claims Supported

9

Support Rate

45%

Support rate

9 of 20 claims supported

9 supported11 partial / not

Claims from this content

11

Partially SupportedThe study group with elevated LDL is trending lower in plaque burden compared to an age-matched control.Partially SupportedThere was no correlation between detected LDL levels at baseline and total plaque score in either the ketogenic diet group or the Miami Heart control group.Partially SupportedA matched analysis between the Lanquist Institute's study participants and the Miami Heart cohort is possible for comparing individuals with elevated LDL.Partially SupportedIn individuals with high hs-CRP, high fasting insulin, and metabolic dysfunction, higher LDL correlates with more atherosclerotic plaque.Partially Supported

Discussion

Native comments, Twitter mentions, and Reddit threads about this content — surfaced together so the conversation isn't fragmented across platforms.

M

Share your read of this content…

Posting publicly as you · linked to your social profiles

Sort by:

AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

NP

N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Individuals on a ketogenic diet with elevated LDL for an average of 4.7 years, who are not on statins, showed no statistically significant difference in coronary plaque burden compared to age-matched controls with lower LDL.

Partially SupportedA study scans 100 individuals meeting eligibility criteria for borderline lean mass hyper-responders at baseline and again approximately one year later.

Partially SupportedThe study utilizes CT angiography with high resolution (down to 1mm or smaller) to scan soft and calcified plaque in arteries, measuring plaque, stenosis, and other metrics.

Partially SupportedA CT coronary angiogram can assess plaque progression in arteries with relatively low radiation exposure.

Partially SupportedCurrent data from a study comparing plaque burden between a high LDL group and an age-matched control is as important as future data on progression at one year.

Partially SupportedIndividuals with hypercholesterolemia would show significant atherosclerotic changes within two years if scanned.

Partially SupportedA healthy human population with elevated LDL and ApoB particles may have the same increased risk of cardiovascular disease as the baseline population.