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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
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The best early indicators of metabolic disease — Whalespan

Content›Video›The best early indicators of…

The best early indicators of metabolic disease

Peter Attia8m · 2021-05-17

Claims Made

13

Claims Supported

10

Support Rate

77%

Support rate

10 of 13 claims supported

10 supported3 partial / not

Claims from this content

11

✓Well SupportedWearing a CGM can reveal glucose dysregulation in pre-diabetic and normal individuals.◐Partially SupportedIdentifying individuals at risk for future health issues when they are still healthy allows for proactive interventions to maintain health.◐Partially SupportedMeasuring palmitoleic acid could serve as an early molecular warning sign for metabolic problems.◐Partially SupportedThe disease process leading to obesity can begin before significant weight gain and is not an individual's fault.Partially Supported

More from Peter Attia

Peter Attia on Zone 2 Cardio

Peter Attia on Rapamycin (with Matt Kaeberlein)

Attia walks back the clinic protocol: too aggressive for healthy adults

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐

Individual carbohydrate tolerance varies significantly, making optimal carbohydrate intake personalized.

◐Partially SupportedPalmitoleic acid (POA) is a potential biomarker for carbohydrate consumption above an individual's tolerance level, increasing as a protective mechanism in the liver.

◐Partially SupportedElevated C-reactive protein (CRP) levels at age 50 predict future health problems, even in individuals who are otherwise healthy at age 50.

◐Partially SupportedElevated palmitoleic acid (POA) levels in childhood or at age 50 predict future health problems like diabetes, even in individuals who were healthy at the time of measurement.

◐Partially SupportedIdentifying healthy individuals with elevated palmitoleic acid can guide them on maintaining their health.

◐Partially SupportedHemoglobin A1c is a late-stage marker for metabolic issues, often appearing 10-20 years after early molecular warning signs.

?Limited ResearchThere is a strong association between palmitoleic acid and triglycerides, with questions about potential differences in its synthesis between racial groups.