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What to look for in experimental studies — Whalespan

Content›Video›What to look for in experime…

What to look for in experimental studies

Peter Attia14m · 2023-09-08

Claims Made

25

Claims Supported

9

Support Rate

36%

Support rate

9 of 25 claims supported

9 supported16 partial / not

Claims from this content

11

◐Partially SupportedThe PREDIMED study's primary results still held after re-analysis despite randomization issues.◐Partially SupportedBlinding subjects in psychedelic studies is difficult due to psychoactive or physical side effects revealing treatment allocation.◐Partially SupportedCrossover studies require careful determination of washout periods to avoid carryover effects.◐Partially SupportedConflicts of interest among authors of clinical trials, such as being a paid consultant for pharmaceutical companies, must be declared.Partially Supported

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Peter Attia on Rapamycin (with Matt Kaeberlein)

Attia walks back the clinic protocol: too aggressive for healthy adults

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AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

NP

N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐

Crossover studies are statistically powerful because they allow for paired t-tests, which reduce variance by comparing individuals to themselves.

◐Partially SupportedA study must be adequately powered, especially if it yields a null outcome.

◐Partially SupportedIt is important to pay close attention to the frequency, severity, and distribution of adverse events when evaluating clinical trials.

◐Partially SupportedA statistically significant result showing a drug lowers systolic blood pressure by only 1 mmHg may indicate an overpowered study with clinically irrelevant findings.

◐Partially SupportedThe PREDIMED study was stopped early due to its positive effect showing a significant benefit of the Mediterranean diet over a low-fat diet for primary prevention of cardiovascular events.

◐Partially SupportedDrug company funding of trials can introduce bias if information is buried in supplemental journals.

◐Partially SupportedDouble-blinding, where neither subjects nor investigators know treatment assignments, is preferred in studies to minimize bias.