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Weekly · Sunday Morning

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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Splenda + carbohydrates disrupts neural signaling — Whalespan

Content›Video›Splenda + carbohydrates disr…

Splenda + carbohydrates disrupts neural signaling

Paul Saladino8m · 2023-01-30

Claims Made

18

Claims Supported

1

Support Rate

6%

Support rate

1 of 18 claims supported

1 supported17 partial / not

Claims from this content

13

✕Not SupportedConsuming sucralose with carbohydrates impairs neural and metabolic sensitivity to sugar.✕Not SupportedStevia and monk fruit may negatively impact gut flora and potentially trigger insulin secretion without calories.✕Not SupportedAspartame consumption may lead to neural and behavioral changes in individuals and their descendants, even at doses below the FDA's maximum daily intake.✕Not SupportedDiabetics should avoid artificial sweeteners, particularly with carbohydrates, due to negative impacts on glucose tolerance and insulin sensitivity.Partially Supported

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AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

NP

N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐

Coke Zero contains both Ace-K and aspartame, while Diet Coke contains only aspartame.

◐Partially SupportedThe evidence regarding the effect of saccharin and sucralose on blood glucose and insulin is mixed.

✕Not SupportedSucralose consumed with carbohydrates negatively alters insulin signaling in human studies.

✕Not SupportedA seven-time consumption of sucralose plus carbohydrate drink in adolescents caused significant dysregulation in fasting insulin levels.

✕Not SupportedDiet Coke is not a benign substance.

✕Not SupportedEnergy drinks containing artificial sweeteners, such as diet Red Bull and sugar-free Monster, are problematic.

✕Not SupportedArtificial sweeteners may negatively impact gut health, glucose tolerance, insulin resistance, and anxiety, with potential heritable effects in mice.

✕Not SupportedDrinking Diet Coke may negatively impact male offspring and potentially induce transgenerational anxiety behaviors in females.

◐Partially SupportedHoney, maple syrup, fruit, or organic fruit juice can be used as sweeteners instead of artificial sweeteners.