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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Anti-seasickness drugs for longevity | Peter Attia & Rich Miller — Whalespan

Content›Video›Anti-seasickness drugs for l…

Anti-seasickness drugs for longevity | Peter Attia & Rich Miller

Peter Attia9m · 2023-12-09

Claims Made

26

Claims Supported

4

Support Rate

15%

Support rate

4 of 26 claims supported

4 supported22 partial / not

Claims from this content

16

◐Partially SupportedFarm-raised Atlantic salmon typically has color added to its feed, such as beta-carotene, to achieve an orange hue.◐Partially SupportedMechine and astaxanthin are available over-the-counter longevity drugs.◐Partially SupportedFisetin was tested as a potential senolytic drug to see if removing senescent cells would extend lifespan.◐Partially SupportedFisetin was tested for its senolytic properties and potential to increase lifespan in mice.◐Partially Supported

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Attia walks back the clinic protocol: too aggressive for healthy adults

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

The drugs ananth and Meine did not change measured maximum lifespan in mice at tested doses, but further dose-response studies are needed.

◐Partially SupportedBonine (meclizine) is considered for use during a trip to Chile due to potential choppy seas.

◐Partially SupportedGino Cimino suggested testing astaxanthin as a potential anti-aging remedy because it is a TOR inhibitor.

◐Partially SupportedAstaxanthin showed a significant lifespan effect in males in the ITP study.

◐Partially SupportedAstaxanthin may influence aging through tour inhibition or other targets.

◐Partially SupportedAstaxanthin may influence AG grade indicators and tissues.

?Limited ResearchThe evidence strength for astaxanthin's alleged health benefits, including anti-histamine, anti-inflammatory, and antioxidant effects, is unclear.

?Limited ResearchThe lifespan extension effect of astaxanthin in male mice was not proven to be mediated by TOR inhibition.

◐Partially SupportedAstaxanthin's beneficial effects in male mice may be related to changes in serotonin or histamine production in the brain, rather than TOR inhibition.

◐Partially SupportedBonine (meclizine) is of interest for longevity research.

◐Partially SupportedAstaxanthin acts as an antihistamine and has CNS effects that help with seasickness.

?Limited ResearchIt is unknown if meclizine and astaxanthin will be effective in humans.