Does exercise slow aging?

Well SupportedExercise provides significant physical, cognitive, and potentially emotional quality of life improvements, even if it had no effect on lifespan.

Partially SupportedExercise increases the enzyme gpld1 in the blood, which in mice is associated with increased neurogenesis and brain-derived neurotrophic factors.

Well SupportedIrin increases in humans and mice after exercise and benefits fat cells.

Partially SupportedElevated gpld1 is observed in mice undergoing caloric restriction, isocaloric restriction, and in lifespan-extending genetic interventions and treatments.

Partially SupportedExercise likely slows aging, but direct evidence is not yet 100% certain.