Ibuprofen, Naproxen, Celecoxib: When Are NSAIDs Actually Appropriate

Well SupportedA short-term regimen of up to 2400mg of ibuprofen per day, divided into three doses, may be tolerated for one to two weeks.

Well SupportedNSAIDs are appropriate for acute pain when they enable functional improvement and engagement with work and social life.

Well SupportedCombining acetaminophen and ibuprofen offers a synergistic effect, allowing for lower doses of each.

Not SupportedLong-term NSAID use can negatively impact blood pressure, heart health, and kidney function, particularly in older adults.

Partially SupportedNSAIDs might delay natural healing and cause more problems by interfering with inflammation.

Ibuprofen, Naproxen, Celecoxib: When Are NSAIDs Actually Appropriate | Sean Mackey, M.D., Ph.D