Acarbose started in late middle age is effective for extending lifespan in both sexes, but less so than when started in youth.

“kagaoan as I mentioned which is an sglt2 inhibitor it worked acarbose a drug that inhibits glucose absorption worked and interestingly didn't require weight loss so the th pis behind giving a carbos to the mice was it's a caloric restriction mimetic a CR mimetic and it worked but then but the but the treatment mice weren't any lighter than the non-treatment mice which actually goes back to something you said at the very outset which suggested that tight glycemic control independent of weight is a longevity benefit the same was true with the sglt2 inhibitor canaga floen sglt2 Inhibitors cause you to pee out more glucose a carbos vents you from absorbing in your gut so two different ways to regulate glucose neither of those experiments resulted in a lower body weight for the mice and yet they both lived longer again there's something very important about regulating blood glucose”

“In mice, the drug Acarbose blunts the spike & they live 4-17% longer 🐭”

“Acarbose, a sugar that blocks uptake of starches, extends lifespan of mice 4 - 16%.”

“Acarbose is an alpha-glucosidase inhibitor prescription medicine that slows carbohydrate digestion. It increases median lifespan in mice around ~20% in males and smaller (~4–5%) in females”

“we used a carbos starting at 20 months of age it worked half as well as a carbo started in youth that is we got a statistically significant change in the maximum lifespan by our statistical procedure in both sexes and a statistically significant change in the males even in the median life span in the females the p-value for median was .07 if memory serves”

“a carbos started in late middle age is effective in both sexes not as effective as if you start it in youth”

“A carbos is another one of the those drugs that actually found a survival benefit in the ITP and it was a very interesting finding because the the thesis for testing it the ITP is a very clever system anybody can nominate a candidate to be tested then the you know the panel over there reviews it and they decide Yep this is interesting we'll go ahead and study it so when I think David Allison nominated uh a car bus to be studied the rationale was it would be a caloric restriction mimetic because you would literally just fail to absorb I don't know make up some number right 15 to 20 percent of your carbohydrates would not be absorbed and therefore you would the mice would effectively be calorically restricted it would pass them out that's right and what happened was really interesting one the mice lived longer on a carbos but two they didn't weigh any less so it what it they lived longer but not through calorie restriction that's interesting yes”

“remember the hypothesis of David Allison who proposed a carbos is this is going to be a CR mimic that induces weight loss because of bad absorption well guess what those mice weighed the exact same amount they just lived a heck of a lot longer suggesting it was actually the glucose metabolism that that gave the benefit”