Andrew Huberman· PhD
the E2 isopor I think showed up God I think 50,000 years ago and the E2 isopor showed up very recently about 10,000 years ago now today we realize that there's a clear stratification of risk when it comes to Alzheimer's disease that tracks with those isoforms so because you have two copies you basically have six combinations of how you can combine those genes you could be 22 23 2 4 33 34 44 um the prevalence of them is basically as follows 33 is now the most common three is the most common so double three is 50 5 is% of the population the next most common is the 34 which is about 25% of the population and then after that most things are kind of a rounding error so uh two threes and two fours uh would be the next most common four fours are very rare and 2 tws are the rarest of them all two tws are less than 1% 4 fours are about 1 to 2%