The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
in the brain you have something called the glymphatic system and the glymphatic system is used to clean out these these amyloid proteins but interesting thing is you're not sleeping the kofedix systems all Craig you lated like 10 to 20 percent during non-rem sleep
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there's a system of ducts in the brain it's called the glymphatic system and it's named because the glial cells of the brain facilitate its function and it sort of resembles the lymphatic system of ducts which is over the body's waste disposal you know the back roads in the body I guess you could call them and when we sleep essentially cerebrospinal fluid gets swooshed through the brain and it cleanses the brain of these precursor proteins that essentially form the backbone of the two characteristic hallmark pathologies that have come to be associated with Alzheimer's disease
one of the critical ingredients that they found that the glymphatic system washed away was a sticky toxic protein called beta amyloid beta amyloid is probably one of the two core proteins that we know underlie your risk for the development of Alzheimer's ergo if you're not getting your sleep at night you're not getting that washing away of the toxic Alzheimer's protein every night then you are building up more amyloid within the brain if you keep doing that night after night it's like compare interest on alone it's just escalating you're out Simas risk
one of the critical ingredients that they found that the glymphatic system washed away was a sticky toxic protein called beta-amyloid
when you go into deep sleep at night this sewage system kicks into high gear and essentially those glial cells which surround the brain cells themselves the neurons proper they shrink in size by up to 200 percent and then all of a sudden it leaves a vast amount of room for cerebrospinal fluid to start perfusing the brain and washing out the detroit the metabolic detritus of wakefulness
There's been two pretty major studies that have come out, one in 2013, which was looking at something called beta-amyloid, which is this potentially toxic protein, that we believe is involved in Alzheimer's disease. There's one study that came out that showed that during sleep, the space between neurons expands, and that gives room for this goopy substance to actually get out of cells and be cleared by the cerebral spinal fluid.
For example, you mentioned Alzheimer's disease, and recently this glymphatic system has been discovered where we now, when we sleep, we know that cerebral spinal fluid squirts up into our brain and literally washes out the amyloid plaques and other buildup of these extracellular aggregates that are in our brain.
the glymphatic system is activated in sleep particularly during slow wave or deep sleep it's a series of vessels that surround the brain and use cerebral spinal fluid to distribute compounds as well as push out toxic waste products and other cellular debris one of these is amyloid beta a protein that accumulates and forms plaques in the brain as we age