The histopathological hallmarks of Alzheimer's disease are plaques and tangles, though these are under scrutiny.

“there's been some debate in recent years as to whether or not the whole amalo hypothesis is real or not there's a bunch of unfortunately false data accusations and that whole thing but my understanding is that if you look at us slice of human brain from an alz a patient that died with Alzheimer's maybe even from Alzheimer that you see plaques and Tangles you see these — subcellar structures and buildup and that our basic understanding of Alzheimer's that's in the textbook and that most people have heard of — is still correct”