Andrew Huberman· PhD
So primarily ApoB would be the single most important lipoprotein that we care about.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
So primarily ApoB would be the single most important lipoprotein that we care about.
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Ted Talk on Apo B, LDL P size and # as better markers for heart disease is a must
the first is digging really deeper into the recognition of the importance of atherogenic lipoproteins so kind of revisiting the idea of what apob is why it matters
you have to weigh it against the apob and the things that are almost beyond discussion
you cannot characterize any phenotype without the apo b it really drives me around the bend
by measuring apob why i'm such a fan of measuring apob as opposed to just measuring lp ldl particle number or ldl cholesterol number is we have one single number that captures the total concentration of apob and while that's pretty well associated with non-hdl cholesterol which is a far better surrogate than ldl cholesterol it's still better
to me is the most important number you want to understand to predict from a biomarker standpoint your cardiometabolic risk or a cvd risk because it captures all of the atherogenic particles
to me is the most important number you want to understand to predict from a biomarker standpoint your cardio metabolic risk a CDD risk because it captures all of the atherogenic particles
if you have now triglyceride rich ldls and they're also their purpose there is to really carry cholesterol what does the body do it has to make more ldls and that means the concentration of apob is going up
by measuring the concentration of apob you can completely and accurately measure the concentration of the arthrogenic particles the majority of which are lbl and the reason for that is twofold the first is that every LDL has one and only one apob 100 particle on it the second is that all apobs are the same size therefore they have a molar weight and by knowing the mass you know the number
the best and easiest way and the most tested way to get an accurate atherogenic particle number is to measure AO B
if somebody has a high HDL cholesterol I don't know what blood test to tell you would always check in apob B we do that in one 100% of people and if it was high we would treat apob regardless of an HDL cholesterol level
Why ApoB is a superior predictor of cardiovascular disease over LDL particle number
an advantage of apob is it allows you to in one measurement capture all of that risk because if you have small if you have you know two individuals like going if you're just using ldlp um as your risk you might miss some of the elevated vdl if you're looking at ldlc you'll clearly Miss some of the size issues um that should be captured in ldlp