Andrew Huberman· PhD
So if one were to decide to take ashwagandha in order to reduce cortisol, given that you want cortisol early in the day to have energy throughout the day, the time to take it as probably later in the day or in the evening.
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
So if one were to decide to take ashwagandha in order to reduce cortisol, given that you want cortisol early in the day to have energy throughout the day, the time to take it as probably later in the day or in the evening.
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Therefore, you would not want to buffer cortisol early in the day. In fact, cortisol peaking early in the day provides an anti-inflammatory immune-supporting, focus and mood supporting effect all day long. So I would recommend that people take their first dose of ashwagandha anywhere from 250 to 300 milligrams. Sometime in the early afternoon and again in the evening, as opposed to taking a morning dose in an afternoon dose.
Divide it into two doses of 250 to 300 milligrams. That's what this paper and other papers like it seem to indicate.
You restrict your intake of ashwagandha to the late afternoon and evening and nighttime hours to keep your cortisol levels low and that you avoid taking dosages of ashwagandha certainly as high as 300 milligrams anytime early in the day.