The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
the take home is that if you have an mth or polymorphism nthfr polymorphism which is methylene tetrahydrofolate reductase polymorphism what you may need to do is just optimize your riboflavin status and the best way to do that is drumroll eat a lot of liver because liver is the best source in the animal kingdom of rival and if you eat two to three i'll get a ton of riboflavin and that will probably be enough to um normalize homocysteine even without methylfolate
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if you have adequate riboflavin this being 3 to 5 milligrams of riboflavin per day someone with a even a 677 C 2 T polymorphism that's homozygous like myself can have a normally functioning MTHFR just by getting enough riboflavin it's this it's the binding site for riboflavin that is affected by that polymorphism and you just need a little more riboflavin
what has been shown in multiple studies is that if I eat enough riboflavin then my homocysteine will normalize in that that MTHFR functions normally riboflavin is the key we also need folate not from a for like acid supplement but from food we need b6 many b12 and we need enough riboflavin
although previously overlooked they say homosysteine is highly responsive to riboflavin specifically in individuals with the MTHFR 677 C tot genotype that is homozygous at 677 our findings might explain why the common polymorphism carries an increased risk of coronary heart disease in Europe but not in North America where riboflavin fortification has existed for 50 years
although previously overlooked they say homosysteine is highly responsive to riboflavin specifically in individuals with the MTHFR 677 C tot genotype that is homozygous at 677
if you get a little more riboflavin than the RDA those of us who have this 677 C tot polymorphism can have a quote unquote rescue
again the people in the TT group that's the 677c C tot polymorphism probably not all of you listening to this have that but many of you may and you can find out your single nucleotide polymorphisms by doing some sort of genetic testing it's very powerful for navigating your life um those people benefit by getting more riboflavin in their diets either from supplementation or from Foods
if you get in this study 1.6 milligrams of riboflavin per day it can essentially improve the function of your MTHFR Gene if you have an MTHFR polymorphism like I do which is homozygous 677 C tot meaning I have a very slow MTHFR Gene
if you get enough riboflavin like the study looked at 1.6 milligrams of riboflavin which is more than the RDA there's evidence that the MTHFR actually can go back to almost the native state even with a 677 C to t