Andrew Huberman· PhD
rarely if ever do we hear that ketamine itself can mimic the effects of bdnf in the brain
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
rarely if ever do we hear that ketamine itself can mimic the effects of bdnf in the brain
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
it's clear there are multiple mechanisms involved and perhaps most importantly with ketamine it's that immediate relief that occurs day of or close to day of treatment and in the days afterwards and it's that long-term relief that very likely is is the consequence of nmda receptor suppression burst activity in neurons Within These mood related circuits bdnf being released and changing neural circuits strengthening them in order to give elevated mood as a consequence of that bursting activity and ketamine mimicking bdnf in other words ketamine acting more or less like a growth factor in the brain in order to make sure that whatever changes occur in those neural circuits to elevate mood are durable that they really are reinforced and last over time