Andrew Huberman· PhD
but one of them is far superior at predicting risk in its apob the number of particles is much more predictive of risk than the amount of cholesterol contained within them
Loading…
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
but one of them is far superior at predicting risk in its apob the number of particles is much more predictive of risk than the amount of cholesterol contained within them
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
you got a lot of options available to you now the one thing I used to use the combo lowest dose statin possible coupled with ezetimibe if there was some evidence of even mild elevation of phytosterol against an all one thing I've noticed and I again I've just been a little delinquent I don't think I've gone back and looked at the trials did the trials show an increase in transaminases with that combo no and I think the only trial it would sure you'd have to look back at sees where I'm sure use the simba statin and ezetimibe improve it yeah and there was nothing more than I just I don't know what it is I don't know what it is I keep seeing him again I will tell you there's not a package insert in the world that tells you you should even be following a minase to judge statin or anything going on in a liver as a result of a statin there's no correlation whatsoever so I'm repeating them and all the time because maybe as a biomarker of fatty liver or something else but not a statin toxicity it's not you know so don't ever let a patient stop because they've doubled their ast whatever amination measuring level on statin not related to anything you got great medically little safety because that's what the guidelines are telling you to do there's not a statin in the world that they're all out of the package insert that you should be following liver function tests yeah again I think part of the problem is like you I'm gonna follow a liver function test regardless I have a very different view of how these things should be I mean their use I don't know who's not gonna do it's part of your chemistry profile you're probably doing on every
what forces them in its particle number now I've also explained all right if that's it April B particle number LDL P is your first biomarker
i've been an nmr guy all my life and as we got better and better we just so often saw totally unexplainable discordance between ldlp and april b the data is overwhelming for apob so i think that's where you should be in today's world as your marker of atherogenic lipoproteins
and the apob assay is pretty standard throughout the industry it's not like everybody's got their own apo b essay diana mark can vary widely