Bryan Johnson's biomarker assessment includes cognitive function metrics such as brain age score, functional connectivity strength, global connectivity index, hemodynamic response amplitude, hemodynamic response latency, resting-state oxygenated hemoglobin concentration, resting-state deoxygenated hemoglobin concentration, total hemoglobin concentration, oxygen saturation, cerebral blood volume, cerebral blood flow, neurovascular coupling index, prefrontal cortex oxygenation, parietal cortex oxygenation, temporal cortex oxygenation, occipital cortex oxygenation, task-evoked hemodynamic response, temporal autocorrelation of hemodynamics, functional brain network modularity, inter-regional coherence, brain lateralization index, oscillatory power, phase synchronization index, mean reaction time, reaction time variability, heart-rate variability, and resting heart rate. — Whalespan
Bryan Johnson's biomarker assessment includes cognitive function metrics such as brain age score, functional connectivity strength, global connectivity index, hemodynamic response amplitude, hemodynamic response latency, resting-state oxygenated hemoglobin concentration, resting-state deoxygenated hemoglobin concentration, total hemoglobin concentration, oxygen saturation, cerebral blood volume, cerebral blood flow, neurovascular coupling index, prefrontal cortex oxygenation, parietal cortex oxygenation, temporal cortex oxygenation, occipital cortex oxygenation, task-evoked hemodynamic response, temporal autocorrelation of hemodynamics, functional brain network modularity, inter-regional coherence, brain lateralization index, oscillatory power, phase synchronization index, mean reaction time, reaction time variability, heart-rate variability, and resting heart rate.
Low risk
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
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First mentioned7 months ago
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