The skeleton rebuilds approximately every 10 years, with 50% of Bryan Johnson's skeleton rebuilt over 5 years on his regimen.

“So I mean a substantial portion of your bone so um you get a new skeleton every 10 years. So it's it's wild. What does that even mean? So you have the ability to like rebuild your skeletal structure. You're you're basically rebuilding every 10 years. I've been doing blueprint for 5 years. So I've basically, you know, if if that law is accurate year-over-year in some kind of uh linear fashion, I've rebuilt 50% of my skeleton uh on blueprint over the past five years.”