Andrew Huberman· PhD
So I would say caffeine causes tolerance, but I would not say it has a particularly high addictive liability, whereas drugs like psychosimulants, like cocaine or opioids, have a very high addictive liability.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
So I would say caffeine causes tolerance, but I would not say it has a particularly high addictive liability, whereas drugs like psychosimulants, like cocaine or opioids, have a very high addictive liability.
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the effect of caffeine doesn't shift from a stimulant to an to a more opioid-like effect the more you take. It tends to just make you less uh sensitive to caffeine over time. It's more of a inverted U-shaped function as opposed to two different curves.