and over time if you're continuing to give these drugs obviously you're going to get all of the fibrotic effects and all of the other negative effects that we say that we've mentioned so far and fibrosis in a in a solid organ is usually the precursive stage to cancer um I think a number of Studies have shown that you cannot get to cancer in let's say a liver or kidney or lung or uterus or whatnot before passing through the fryboarding stage words