Andrew Huberman· PhD
The way we look at cardiovascular risk now is way more complicated. And we need to look at the quality of the cholesterol, which is the particle size and number.
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The way we look at cardiovascular risk now is way more complicated. And we need to look at the quality of the cholesterol, which is the particle size and number.
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Tom even you have admitted that the quality of the LDL particle matters, thus there are more variables at play than simple apoB.
So, I can show you those. I will share that. Um so, here is something that I did from This is from July of 2022. And the first one was with Meric Health, and this one is through WellnessFX. And so, you can see my apoB um here, my Lp(a). You can see the LDL size, which is lower than I've had in the past. You can see the particle number, the LDL phenotype, small LDL. Let you just uh whatever you want to see here, I can I can scroll and show you. Sure. I'll just stop right there at that the LDL particles. So, this is what I talk about with patients that it's the particles that predict risk. It's not the cholesterol. The cholesterol is just a passenger inside the lipoprotein.
we would have no way of knowing from this what your LDL particle number would be or your a PO B which would be better predictors of your risk than any of these numbers here
if the doctor didn't do it you demand you do it instantly cuz otherwise you don't know your lipid related risk
either a PO B or LDL particle number correlates a lot better with clinical events or the presence of atherosclerosis
I would list LDL P as one of the five most important metrics I've talked about this that every patient should know their LDL P or a PO B
in virtually every single trial ever looked at the risk follows the particle metric more than the cholesterol metric
but everybody else April B leop those are the tests you need
so at the end of the day it's I got a normalize April be your LDL particle number
and people who really are worried about it you think iris you've got to use particle numbers to make the proper clinical decisions
frankly i find it much easier to explain to patients what apob is than to explain what non-hdl cholesterol is
just how many doctors especially in the us don't even look at apob so the importance for people listening to this too is when they go to their doctor and they're going to run their labs just making sure to bring up is it possible to get an apo be ran