LDL particles of any size can enter the sub-endothelial space of blood vessels.

“an LDL particle is between 20 and 22 denominators but if you look at the space between the endothelial cells that lie on the inside of a blood vessel it's about 70 nanometers so it doesn't really matter how big our LDL particles are they're always going to move into that sub endothelial space”

“it's whether or not the LDL gets stuck because all those numbers you still have a colossal amount of LDL moving into the 17th elio space”

“so it is certainly the case theoretically that you could have a very high LDL but by hook or by crook if your LDL particles don't get retained in the sub immaterial space and don't kick off an inflammatory cascade you're not going to suffer the effects that you otherwise would but all things equal we would love to see a lower LDL particle number because the process by which those particles enter the space seems relatively stochastic”