Paul Saladino· MD
so genome-wide Association studies are surveys of people who have genetic polymorphisms which cause them to have a high LDL well this isn't the same thing right high LDL perhaps this is the fundamental flaw that most of these people are making in their thinking that that for that assumption to be valid for the rest of us that has to be the same condition as a high LDL on a ketogenic or a carnivore diet which is not the case you have a genetic mutation a genetic polymorphism in CET p or pcsk9 or one of these other LDL receptor these are the familial hypercholesterolemia people for some in some sense but there are genetic polymorphisms which cause people to have a high LDL and they'll say oh look there's a linear progression in the in the amount of coronary events in the LDL in the G wasps and the people that have these polymorphisms and I say that is not representative of generalized population those are people who have broken cholesterol metabolism because they have a polymorphism we would never do that anywhere else in medicine we'd never say hey you know this this genetic mutation this genetic disease gives you this condition therefore we're gonna we're gonna just expand that and apply that to everyone else in the population as a blanket statement that does make any sense so will spurious yeah it is a little spurious so people need to be very careful and again this is where I think the onus is on the investigators and people are not doing a very good job of communicating what does G waz what is Mendelian randomization the other studies are the Mendelian randomization x' and these are all genetic people these are people with genetic polymorphisms that affect albian LDL metabolism