The fifth percentile for ApoB from the Framingham Offspring Study is 62 mg/dL, the 10th is 70 mg/dL, the 20th is 78 mg/dL, the 50th is 97 mg/dL, the 80th is 118 mg/dL, and the 95th is 140 mg/dL.

“if your mace risk is less than 5% the thinking is you do not need to treat LDL or apob”

“fifth percentile from the framingham offspring study was is 62. i just in my mind keep keep 60. 10th percentile is about 70 20th percentiles 78 so i just think of 80 50th percentile is about 100 it's technically 97. 80th percentile 118. so i just kind of think of 120 95th percentile is 140.”

“so if you have somebody whose apob is 160 milligrams per deciliter there's a risk reduction that comes to lowering it from 160 to 100 and lowering it from 100 to 80 and lowering it from 80 to 60. what do we know about the risk reduction in lowering it say from 60 to 40 to 20 and I ask both what we could infer pharmacologically and non-pharmacologically in other words from the mendelian randomization versus the pharmacologic”