Andrew Huberman· PhD
So there's a whole category of people called lean mass hyper responders. You're maybe one of those, where you're fit, you're healthy or athletic. And you eat saturated fat, and boom, your numbers kind of go wacky.
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So there's a whole category of people called lean mass hyper responders. You're maybe one of those, where you're fit, you're healthy or athletic. And you eat saturated fat, and boom, your numbers kind of go wacky.
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identifying the lean mass Hypes phenotype which hopefully your listeners know but for anybody who doesn't it's the Triad those three that we talked about earlier but at a more extreme level so people who typically have an LDL of 200 or higher uh typically have HDL of 80 or higher and triglyceride of 70 or lower and all three of those together all three of those are already rare individually by themselves but these three together are actually very prominent in the low carb Community where people are otherwise lean and metabolically healthy
the lean mass hypersponder phenotype is a term coined by dave feldman which is low triglycerides high hdl elevated ldl
I believe there was a higher secretion of vldls overall for those people with lean mass hyper responders
I think Tom would deserve the credit for that in fact it'll probably come up many times throughout this discussion and will certainly linked to it Tom wrote a really fantastic piece on this in his lip holux series I think it was in 2013 might have been 2014 but it was following a number of cases that he and I had shared back and forth about this phenomenon
I would speculate if you were to grab a whole bunch of people who are and will hopefully get into this model that I'm talking about that I call lean mass hyper responders people are at the far end of the spectrum they are athletic they are thin and they are very very low carb and therefore see very high levels of LDL C and LDL P but they also have very high levels of HDL C and low levels of triglycerides I suspect that they would show a very high rate proportionally a VLDL secretion that there actually are trafficking a lot more for their energy triglycerides in the LDL particles and therefore have succeding LDL particles as to the explanation as to why their LDL CN l-dopa would be higher
I believe there was a higher secretion of vldls overall for those people with lean mass hyper responders which is very relevant to our discussion and that way if there's I know that it's a theory I'm not saying that what I'm saying is if this arrow is fatter if the VLDL secretion is at a greater degree it would make sense why there would be more remodeled final LDL particles remaining and why we would see the inversion pattern in the first place because it originated in order to deliver more of those triglycerides which was brought about