Paul Saladino· MD
Like, is that clinically useful? Does it lower apoB? Does it improve endothelial function? That'd be interesting, but if it doesn't do those things, I don't really care what it does to LDL cholesterol.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Like, is that clinically useful? Does it lower apoB? Does it improve endothelial function? That'd be interesting, but if it doesn't do those things, I don't really care what it does to LDL cholesterol.
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
the thing about it you mentioned like the lower LDL like is that clinically useful does it lower April B does Improvement ethyl function that'd be interesting but if it doesn't do those things I don't really care what it does the LDL cholesterol
we also talk about why it has been so complicated to use pharmacologic interventions on the HDL side of the equation to impact atherosclerosis conversely of course it's been the easiest thing I would say in medicine and perhaps the greatest success of modern medicine especially as it comes to cardiovascular disease has been our ability to manipulate the APO b side of the equation as opposed to the APO a side of the equation